Marcello Masssimini, M.D., Ph.D.

(Scientific Advisory Board)

Marcello Massimini, was trained as a Medical Doctor, received a PhD in Neurophysiology and is currently Full Professor of Neurophysiology at the University of Milan. he devoted his research to understanding what changes in thalamocortical networks when consciousness fades and recovers. After studying the basic mechanism of EEG oscillations by means of intracellular recording of cortical neurons during anesthesia, he performed the first high-density EEG recordings (256 channels) in sleeping humans to describe the spatial-temporal dynamics of sleep slow oscillations. Subsequently, he focused on the development and validation of a novel technique (TMS and simultaneous hd-EEG) to study cortico-cortical interactions by a perturbative perspective. Employing this approach during wakefulness, sleep, dreaming, different types of anesthesia and brain injury, he demonstrated that consciousness is tied to the brain’s capacity to integrate information. These experiments shed new light on the mechanisms of loss/recovery of consciousness and led to the development of a bedside index of brain complexity, which has important consequence for the stratification of non-unresponsive patients. Besides neurophysiology, he is interested in the theoretical and philosophical implications of the neuroscience of consciousness.

Dr. Massimini’s work has been published in important scientific Journals such as Science, PNAS, Nature, Nature Neuroscience, Science Translational Medicine, Current Biology, he acted as PI in several European projects (FP6, FP7, H2020, SNF Sinergia) and is a recipient of the James S McDonnel Scholar Award 2013.